Know of any guides on how to fly the B17. Don't mean the basics like take off and landing but in depth guides to dealing with a damaged aircraft like keeping engines functioning, saving fuel and what instruments to look out and what ranges to keep them in etc.

The Readme.htm that comes with the game gives some good information, as does various parts of the manual. I especially recommend reading the sections of the manual titled "Pilot's School" and "Engineer's School". I'm not sure I can give much more advice than this; managing the more realistic aspects of the game are a bit too complicated for me.