So worked for the first couple hours, now whenever I try to launch the game it keeps minimizing. I am running windows 10, I initially tried using the unofficial patch, but at this point I have reinstalled the game several times, both with and without it, no luck solving this issue. I have two monitors, not sure if thats the issue.
Not even sure if its just Arcanum, Fallout 1 and 2 used to work but now they minimize too.

IT is an old post, but I had the same issue with some GOG games. Usually, this is caused by another program running in the background. Closing other programs would always solve this issue.