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I've been trying to use good ol' Google to find an answer to no avail.

Real quick; is there any consequence declining quests from NPCs when playing a continuous game?
This question / problem has been solved by gunman_image
No.

Only if you are trying to get the "Always at your service!" achievement or trying to complete a multi-part quest.
avatar
gunman_: No.

Only if you are trying to get the "Always at your service!" achievement or trying to complete a multi-part quest.
Thanks, bud.