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So I also had this frustrating problem with being unable to run the game - no error message, just nothing happening after either clicking the game shortcut or trying to launch it from GOG Galaxy. I'm on Windows 10 Pro 64bit, BTW...

Now I finally got it running (after some googling and experimenting). Ain't sure which of these steps are crucial and which may be completely superfluos. Anyway, here's what I did:

1) Installed Visual C++ Redistributable for Visual Studio 2012 Update 4
https://www.microsoft.com/en-us/download/details.aspx?id=30679

2) Installed Visual C++ Redistributable Packages for Visual Studio 2013
https://www.microsoft.com/en-us/download/details.aspx?id=40784

3) Restarted the computer

4) Ran GOG Galaxy as Administrator.

5) Ran XCOM2 from the Galaxy UI.

Finally, it works! Please take note that this is not a perfect solution. I had to restart my PC and/or GOG Galaxy (closing its related processes via Task manager too) a few times when the game refused to run again. Anyway, I'm consistently able to run it again after few attempts at most. No crashes so far when the game does run. I guess the most important step is actually running the Galaxy client as Administrator as none of the above worked for me before I tried this. Hope this helps someone!
Post edited December 31, 2022 by StrixCZ3
Thanks dude!!! Worked for me too!
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mdjackson81: Thanks dude!!! Worked for me too!
Glad I could help - it was driving me mad as XCOM 1 is one of the best tactical games I've ever played so being unable to enjoy the sequel I already paid for would be hard to swallow...
i contacted gog 4 days ago after buying it and had the same problem as you i think. wouldn't start, but i had missing dll. messages. I've waited 4 days with no reply from them, so i like you went and looked up about the missing dll files. i installed Microsoft visual c++ redistributable 2013 version 12.0:40649 as my research shows that they come in it. must be windows 10 pro don't install these.

installed and the game started.

GOG perhaps you should include this file pack when you install the game.
thank you strixcz3 for starting this post
thanks for sharing, unfortunately didnt help here :(

xcom 2 vanilla work, but trying to launch game from gog galaxy ( with war of the chosen expansion) game just crash after showing xcom 2 logo
Thank you for this solution.