Palestine: Asidhu, hello to you. (^_^)
With the minor exceptions of accessing the pause/in-game menu, along with bypassing/skipping certain (not all) cut-scenes/forced mission briefings (all of which seem to require the usage of the [Esc] key), 'World in Conflict' *is* playable while using the mouse, exclusively.
Camera North, Northeast, East, Southest, South, Southwest, West, Northwest (Replicates [W] [A] [S] [D]) = Hold [Middle Mouse Button]+[Right Mouse Button], followed by mouse movement in the desired direction.
Camera Zoom In/Out = [Middle Click/Scroll Wheel] Up/Down.
Mouse Look = Hold [Middle Mouse Button], followed by mouse movement in the desired direction/axis.
Current camera location can also be instantly teleported across the map with the usage of the mini-map, located on the lower-left side of the screen.
After selecting a unit, or a group of units, special abilities, as well as other options (such as dismounting soldiers from vehicles), can all be activated within a graphical user interface box, located in the lower-right side of the screen. This panel stays active as long as at least one unit is selected.
Support options, and reinforcements, can be utilized by clicking on the relevant icons in the upper-left and upper-right portions of the screen, respectively.