RChu1982: As stated, what would happen with a level 50 Human Fighter with maxed Vitality? I'm assuming that Hit Points would be around 500 or so. This is obscene, as nobody will ever get to level 50 normally. Said character would (if built correctly), have maxed all but Intelligence (74, as Powercast is the one expert skill that doesn't help a Fighter).
Better: Make the character a Dwarf. This gives you some extra damage resistance, which *stacks* with Iron Skin, allowing you to take even more of a beating.
Now just add Body of Stone, at a high enough power level, and you can now reach 100% Damage Resistance. Now you're outright immune to physical attacks, and to status aliments caused by physical attacks. Now the only things that can hurt you are spells and special attacks, and HP damage from those sources isn't significant (aside from enemy use of Crush or similar spells, but you do have enough HP to survive those with this build).
Some other classes to do this on:
* Bard: There's a piece of Bard exclusive equipment that boosts Iron Skin. So, as a Bard you can get even *more* damage resistance.
* Monk: Monks get innate damage resistance, which *stacks* with other sources. This means you'll take even less damage from attacks targeted at you. The catch with this build is the Stealth skill, which can't be turned off, and for this build you would ideally want to turn it off if you could. Also, this is an apprentice build.
* Bishop (or Alchemist): You get the Vitality (and hence damage resistance), *and* you can cast Body of Stone on yourself. Lower HP than the above options, but once you have 100% DR, you don't really need it. For dealing with spells, Realm skills boost resistances, and Intelligence (because Power Cast makes sense for this build) boosts Mental resistance.
By the way, one catch with this build, particularly the Fighter version: PL7 Restoration won't be enough for a full heal, as I'm pretty sure you'd have more than 350 HP by this point. (A level 50 Fighter with 50 Vitality already has 459 HP according to my calculations; more Vitality increases this number further.)
Although, one thing I'm wondering: Can such a character survive a fall from Trynton?