Currently Wiz8 does not run on OSX high sierra unless you go to contents>resources>game>wizardry8> wineskin. set screen options > uncheck "Auto Detect GPU".

Now, a nice upgrade I have found:

Go to the Wizardry 8 directory by right clicking "show package contents" (contents>resources>game>wizardry8>drice_c>programfile>Wizardry 8

Open with TextEdit >3DVideo.CFG
Replace Glide2x with OpenGL
set the resolution at 1024 x 768 from the 800x600
set bits at 32 instead of 16. Quite a great graphics improvement, check out the clouds. Also the automap becomes A LOT quicker and reactive.

Now if you launch the game everything will work except for the cutscenes.
Go back to the Wineskin wrapper (contents>resources>game>wizardry8>Wineskin) set screen options, and check "Use mac Driver instead of X11". Uncheck "Decorate windows".

Everything should work beautifully and super smooth. In the game I uncheck Mip Mapping, it makes things way to smooth for my taste.
Enjoy!

I forgot to mention, with OpenGL you will need the aa004's OpenGL fix file (srDD_OpenGL.dll) for non-nvidia cards :
http://www.zimlab.com/wizardry/recovered/wolfie/Wizardry8BUG-FIXES.html

Copy and replace the same file in your Wizardry 8/Dll folder.
Otherwise you will get black grid lines running through your wiz8 graphics.