artician: Can anyone tell me if there are any ways to handle combat that are better than others? Does switching the type of attack do much to improve your hit chances? Does moving around make a difference? Should I be constantly dodging?
On the recommendation of others I went with a strength-favoring druid.
Thanks!
Usually you'll want to handle combat with melee weapons (which includes your fist, a perfectly viable weapon if you choose to put the points into that "weapon" skill). All of my advice here applies to pretty much every character.
Moving around makes a HUGE difference in your combat performance, and you should almost always be dodging in and out of melee range. Close in on enemies that use ranged attacks (mages, imps, gazers, etc.) to make them switch to melee, which usually lowers their damage output (gazers perhaps being the notable exception here, though even they go down easily after you've powered up). You generally don't want monsters throwing fireballs or lightning at you.
I almost always use just the mouse for moving around. If you start charging a swing while moving, you can keep moving while charging. If you start charging a swing while standing still, you will NOT be able to move (with the mouse, don't know about keyboard) while you are holding that swing. Practice starting a swing while moving, and practice moving forward and then backward while swinging. You can unequip your weapon and practice by punching a wall while weaving; you'll be able to see the damage graphic pop up to help you get a feel for distance and you won't risk damaging your weapon of choice while practicing (no, you don't take damage from punching inanimate objects). Dodging in and out can help you avoid a LOT of hits from dangerous foes, and you may be able to escape damage entirely if you consistently back out of range by the time they start their attack. Things like Reapers, Trolls, Golems, and Dread Spiders can be lethal if you stand and fight, but are significantly less so by dodging in and out of their range when you go to land your own hits. If you find yourself backed into a corner, you may be able to get more space by running forward into your opponent; if nothing is behind them, you can push them backwards (though not off ledges, and you'll definitely be in their attack range while doing so).
You should pick one weapon skill (sword, axe, mace, or unarmed) to use for the game, and put points into just that skill. Also add points to the Attack skill. Both of these skills influence how often you can hit an opponent and whether you damage your weapon while trying to do so. As mentioned, swords are an excellent choice for your first game, but any of the others are perfectly viable (I've used Unarmed to complete the game when I was using a low strength character). Choosing Missile weapons is not a good idea for a first play through: you can't shoot when at melee range, monsters that don't have a ranged attack are going to try and move into melee, monsters that have a ranged attack are likely to out damage you in ranged combat, ammo is both limited and heavy, and the targeting can be rather wonky. In my experience, any targeted combat spells end up functioning similar to range combat. Do keep a wand or two of magic arrow around, in case you are fighting a lurker and it tries to flee; pop it with a magic arrow and it will come back so you can kill it.
Someone else has already talked about charging to full power (the green orb color) before releasing your swing. I second his statements.
I don't know if different types of swings are better for particular weapons; I usually just use the cross-body swing (slash?). I also don't know if skeletons take more damage from maces; I have had no issues killing them with other weapon types. Just pick one (melee) weapon class and use weapons from that class during the game and you should be fine.
dtgreene: Why should whether the game is an RPG determine whether you should use the weapon you like more? Is there any reason why, in say Castlevania or Mega Man, I shouldn't use the special weapon I like the most?
You shouldn't use your favorite special weapon if it won't accomplish whatever you are trying to do. For example, if your favorite special weapon won't kill a particular boss, then you should probably choose something else. It doesn't matter how cool you think the Flash Stopper is, you shouldn't use it against Metal Man. :P