Wow, my first game to actually buy from Gog and this happens.

So I installed and reinstalled it and it remains unresponsive to my mouse clicks... I can see the mouse moving but no clicks are accepted... My mouse works fine and is not failing me in anything else like web browsing or playing other games.

Any hint? This is a poor start.

I had to remove my Joystick, Throttle, and Rudder Pedals from the USB ports. It was showing Console Controller X but now that's gone and the mouse works fine. Also under Mouse Properties > Pointer Options ... make sure 'Enhance pointer precision' is unchecked. Good luck!

I unplugged the usbs except for the mouse and keyboard. I made that small change.

That didn't work.

might be related, i'm using an Xbox One controller connected via USB and i'm encountering the same thing, pressing X (like mouse clicks) will not go through. I have to frequently disconnect and reconnect the USB cable for the game to respond.

no issues with the controller on other games like Witcher 3, Mass effect etc.

I have the same problem, Witchers , please help !

I'm not using a joy stick.