Hickory: Yes, this is required for Blood and Wine.
Boeriemore: All that is available in Gog downloads is patch 1.22 part 1 and 2.
Do I need both these do the job?
Ok, this isn't getting us anywhere. Here is what you should do, so that no errors are made:
First, download these files from your account, and place them ALL in a temporary folder. I suggest C:\Downloads\TW3\
TW3 1.10 main installer (files 1 to 8)
Patch 1.22 (files 1 to 2)
Free DLC 1.22
Hearts of Stone 1.22 (files 1 to 3)
Blood and Wine 1.22 (files 1.to 3)
You do NOT need the multi-language pack if you play the game in English
Now, uninstall the game from Control Panel. Keep your saved games when it asks.
Now to reinstall the game. Run the setup files in this order (remember you ONLY need to click the .exe files):
setup_the_witcher_3_wild_hunt_2.0.0.40.exe WAIT for it to finish installing, it can take a long time, Be patient. patch_witcher3_1.10-1.22_2.0.0.45.exe WAIT for it to finish installing. setup_the_witcher3_dlc1-16_2.0.0.45.exe WAIT for it to finish installing. setup_the_witcher3_exp1_2.0.0.45.exe WAIT for it to finish installing. setup_the_witcher3_exp2_2.0.0.45.exe WAIT for it to finish installing. Once the final one is finished, your game is clean and fully up to date.