As for the RAM issue, 4GB should be plenty. I seldom see it holding more than 2GB and honestly I've seldom ever seen my system utilize half of the 12GB I have.
Stability is a crapshoot though, as the memory management seems a little flaky at times. For me, I still get CTD occassionally when entering cutscenes, or when loading games, although windows doesn't show an error, it has to do with the cpu core
hitting 100%, maybe setting core affinity for all processes prior to launching the game is the only thing left that I haven't tried.
PSU- Don't skimp on the PSU at this point. Although you might not need the extra power now, having to replace it when you add another gpu or add some other power hungry device. Secondly, hopefully someone knows the site, there is a site that reviews psu's that I wish I had taken the time to review as I find my psu wasn't a wise purchase, it just isn't that efficient, and I need around 800+ so they start to get pricey, and paying 20$ more that is more efficient will be worth it in the long run. So I suggest once you figure out what parts to add, use a psu calculator, run it to see what size psu you'll need. Then run it again and see what you'd need if you added RAM, an extra HD, and an extra GPU, Since these are the components most frequently added to most rigs until you decide to replace the mobo.
One thing I don't think anyone even brought up, CPU Cooling, are you planning on air, or water cooled. But definitely buy a serious cpu cooling system. Air cooled I'm partial to the Noctua's but depending on the placement of the RAM and the clearance, for the board you want, there may be better fits for your style. Also buy good heatsink paste, I'm sure the vets that have weighed in will say Arctic Silver 5, or an equivalent.
Also make sure the case you choose has the clearance for the vid cards.
It's the little things, that make building your own rig, worthwhile and aggravating. Like forgetting to order a cable or the thermal paste or not having the right sata cable or ethernet cable, adding that neon flair or customizing the case, and the lack of warning beeps when you power up for the first time.
And remember that the size of the monitor screen(resolution you want to run it at) will determine how hard your gpu will need to work. I say this because your talking about running at 1080p. So I'm guessing you're thinking of attaching to a newer tv, if not just dismiss this. I've heard that to reduce stress that the tv's native resolution and I am just making up numbers here, forgive me, if its something like 3000 x 1500 that you should choose a resolution that's a straight fraction, ie 1500 x 750 would be what you'd choose. choosing something like 2000 x 1500 would cause the gpu to have to work harder to produce the image because more calculations, adjustments have to be made. I don't claim to know the exacts, as it was just one article, but it made sense to me.
Good Luck, take your time and research parts. You probably have plenty of time before the patch is released to find the best bang for your buck.
asus p6t deluxe/ i7 920 /win7 64 pro
12GB OCZ RAM
460 Gtx v2, 260 Gtx *removed since w2
3 Samsung Spinpoint, 2 WD (4.5 Tb)
and a bunch of other crap