I'm sorry, but that's not really enough information to help you with. I suggest that you read the official support page and look at some of the information there: http://www.en.thewitcher.com/support/faq/

I'm having a similar issue. I start the game, the intro videos play right up to the CD Projeckt video and then the game crashes back to desktop.

I'm using an HD5770 card and I tried playing the game on a system with a GTX590 and it worked fine. I've tried updating to the latest drivers, re-installing the game, playing in a window, reducing the resolution right down to 640x480 with the lowest settings and nothing seems to work.

Any help would be appreciated.

I do Everything but it's still not working.
I download new quest register game, but i cant play.
I bought this game 23 may and i am very angry.
when i want to open witcher2.exe in bin folder i see error. : (

What is your desktop resolution? There is a known problem of TW2 failing to launch if your vertical desktop resolution is over 1920. Dropping desktop resolution helps.

Have you tried going straight to the witcher2.exe and run it as admin.

1440x900 19 cal monitor when i open by admin i see error too