I have just tried to run this game. It starts up fine. I can get to the start screen, but when I try to play the game, or rather the first scene is where the trouble starts. The screen goes black then the scene comes back. It repeats this until I have to manually quite the game.
I have these details of my Graphics card. I hope these help
Processor: Intel(R) Pentium(R) D CPU 3.40GHz (3401 MHz)
Operating System: Windows Vista (TM) Ultimate, 32-bit (Service Pack 2)
DirectX version: 10.0
GPU processor: GeForce 9400 GT
Driver version: 190.38
Stream processors: 16
Core clock: 550 MHz
Shader clock: 1400 MHz
Memory clock: 400 MHz (800 MHz data rate)
Memory interface: 128-bit
Total available graphics memory: 1918 MB
Dedicated video memory: 512 MB
System video memory: 0 MB
Shared system memory: 1406 MB
Video BIOS version: 62.94.4B.00.77
IRQ: 16
Bus: PCI Express x16

Give this a try:
Browse to the folder The longest journey is installed in, and open the preferences file with notepad.
Within the file change "bool_UseHardware=1" to "0" then save the file. Run the game and it might stop it crashing.

Thanks for the reply. I have just tried it but no such luck. I even told it to run in windows mode, but it still runs in full screen as well

Ah yes, sorry I didn't see you'd replied about this in the other topic. How about going to the "Game.exe" and editing the preferences, switching it to compatibility mode with Windows XP?

I have the same problem as Trecaa, but my OS is Windows XP...so compatibility mode won't help.

To run in windowed mode you have to edit the preferencess.ini file in
C:\users\<user>\AppData\Roaming\The Longest Journey.
You'll have to add these two lines:
[DirectX]
bool_StartFullscreen=0
I'm on Win7 64 bit, running gog's version on a GTX295 wit the same drivers you have (190.38) and i'm not having any problems...

had same problem on win 7 x64 with 190.62, game is totally unplayable out of the box, the black screen is because TLJ crashes graphics driver but vista+ systems have this cool ability of recovering crashed graphics driver and that's the blinking you noticed, TLJ crashes driver, vista recovers, then TLJ crashes it again :) until alt+tab or ctrl+alt+del. I got around this by starting the game, then alt+tab to win & back to TLJ, strangely it runs then but with various graphical glitches like april's hands always on top, even when they are behind an obstacle. In the end I had to settle down for compromise, software mode is best choice for me (adding the bool_UseHardware=0 into preferences, I have no problems with that, even in fullscreen), or play game in VM....
I think you're using wrong file, that in program files doesn't seem to be used by game, try .ini in C:\Users\<you're acc name>\AppData\Roaming\The Longest Journey
for example if you need software + windowed mode add this
[DirectX]
bool_StartFullscreen=0
bool_UseHardware=0

downgrading the driver to 186.xx worked for me. As I have other applications that need driver wersion 190.xx this situation is not directly satisfying...

A Big thank you to everyone who posted to help me out. I changed the Preference file in Apps and it has worked.
I must remember not to reposition the game window thought, as the game plays in the window fine, but the movies play on the screen where the game first opened.
I don't know if that makes sense.
I also haven't played it for long. Does this also fix crashes of the game. I remember trying to play this under XP and the game would crash on me.
But anyway thanks again to everyone who helped.

I'm doubt it was the driver's fault, though. I'm using 160.62 and TLJ runs perfectly (then again - I have Win 7, 32-bit).
If anything - I'd check if you have "force single buffer" checked in configure.exe...
You can always try it my way ;).

Do you force any custom 3D settings like anti-aliasing or anizo or anything similar?
If so, try disabling it and check again.