groze: Unfortunately, Sanitarium is a very buggy game, and though I never had any issues, personally, Chapter 3 seems to be one of the worst offenders when it comes to bugs and crashes.

The old RPG motto, "save early, save often" goes for adventure games as well, and this is especially true in Sanitarium's case. You never know when the game is going to crash on you, so you'd better make sure you save really often and as early as you can.

If you're running Windows 7, make sure Sanitarium (and any other game, for that matter) isn't installed under the 'Program Files' folder. In fact, I would highly recommend installing it on something like 'C:\Sanitarium'. Try messing around with compatibility options, trying different ones to see if any one makes your game more stable, never forget to run the game as administrator -- and, if possible, when installing it, run the installer as administrator, as well.

These are all basic and generic recommendations, but if you don't feel safe enough to try the regedit fix, they are things you could try before having to resort to that.

I hope you get to fix and play Sanitarium, since it's one of the best, most unique games ever made.