Try to run the game several times, maybe one of these works(the same happened to me, I had to install it in Linux in order to run propertly).

Can you give us your operating environment? Are you perhaps trying to run this game on a Netbook, or perhaps Intel graphics adapter? I would be happy to help you run this game but do need more details.

Alienware m11x r2
i7 processor (overclocked, of course)
4 gig mem
Nvidia 335m

Uninstalled the game... The reinstalled about a week later... Been working perfect since.. Oh well

I wont point the finger at overclocking.... But have you tried to rerun the setup program again to select a different graphics mode?

Is your resolution set high (eg 1440x900) but using the 16-bit colour scheme?

I have Windows 7 home premium 64-bit. I've just installed Rayman 2 from GOG, version 2.0.0. The game fails to load, all I get is black screen and I have to reset to get out. Also running GXsetup results in black screen. I've also tried nglidesetup, but no use.

Any ideas? I am running everything in administrator mode. My graphics card is Geforce 210.

P.S. I had an older version of the GOG Rayman 2 installed for awhile and I got to GXsetup but no use, starting the game resulted in black screen too. I uninstalled that before installing the new version.

Edit: I just got it to work. I did a bunch of things: updated the nvidia display driver and played with the ubi.ini settings manually. BUT, I think what finally solved it was that I first changed my desktop resolution to 1024x768 and then started GXsetup. From there I selected the glide driver and resolution of 1280x1024. Then hit save and bang! the game starts (after some screen flickering, but nothing serious).

After I played the game a little I changed the desktop resolution back to where it was (1360x768) and the game still works. So weird... Still the game runs at a resolution of 1024x768 but that's okay.