On a related note its kind amusing, but all classes can pretty much do all thief subquests (even if having those skills will lock out some "paladin" or other class specific sub quests in QFG5). Of course some quests and variant solutions are changed depending on which class you are playing, and some items will only appear if you are playing a specific class. In particular in the later games. But most hybrid classes with thief skills will be able to access most thief 'heist' quests (in 1, 2, 4, and 5).
But thieves can't do all quests of any other class (they are locked out of quite a bit of things). All classes can access most or all of magic user quests in 1 and 2. However, due to the nature of the differences in stories and events based on class, they will not be able to access magic user quests in QFG3, QFG4, and QFG5. These alternate 'storylines' and 'events' would be impossible to all happen in a single game, as they generally contradict each other (i.e. putting items or characters in very different locations depending on the class).
The thief's quests in 3 is actually particulary limited (as there are few areas to actually steal things in that game). The puzzle get the drums is and spear for example rely on thieves skills, but those are not accessible to any other class (each class gets a different set of puzzles, and encounters depending on their specific class), and the ending battle with the demon is scripted differently for each different class.. How you access events in that game and order you access them are very much class dependent.
Becoming a paladin is impossible if you do the thief quests in QFG2. It may be possible to become a paladin in QFG3, without doing anything 'thiefy (but only if you are a fighter class)'.
In other words the only legitimate way to become a paladin through 'full hybrid' methods, will require a player to start the series as a fighter (and either refuse to do thief quests in 2, or wait until 3).
But a paladin probably should avoid thief skills altogether (at least no points in lock picking), if they want to access all there is to access for paladins in QFG5.
Post edited October 05, 2013 by Baggins