Making a weird "buzzing" noise...
I'm running it on my Mx17

Hey did you ever solve this? I have the same problem, I'm looking into it though.

I went through the dosbox config and changed all sample rates up to 44100 from, e.g.:

rate=22050

becomes

rate=44100

and the same for GUS, Soundblaster et al. On a wim I also changed the [mixer] sections prebuffer from 10 to 20 ms. The whole mixer section thus read:

[mixer]
# nosound -- Enable silent mode, sound is still emulated though.
# rate -- Mixer sample rate, setting any devices higher than this will
# probably lower their sound quality.
# blocksize -- Mixer block size, larger blocks might help sound stuttering
# but sound will also be more lagged.
# prebuffer -- How many milliseconds of data to keep on top of the blocksize.

nosound=false
rate=44100
blocksize=2048
prebuffer=20

Yes, did those changes help at all? This was 3 odd years ago though, pre Gog Galaxy so it's possible things have changed. If that didn't help at all reply back and I'll see if I can reinstall and:

a) re-create the problem.
b) fix it again. :D

I'm running Windows 10 now though but we can try.

I am also running Windows 10. I tried the dosbox config change. I didn't notice a difference in game. Just after the intro the first conversation is already bugged with an annoying high pitch tone. I quickly gave up the hope of solving this, however. Thanks for the help anyway, I think I will just go with the next game in the series for now.

Fair enough, I just got back from a weekend away. For the sake of completeness in case anyone else comes across this thread I'll re-install and have a play.

Was going to document this as I go but I've tried everything and got nowhere. I've tried fixing CPU cycles, copying the PQ4.gog to PQ4.iso and mounting it, then editing resource.cfg (the one in the game directory that the launcher uses, NOT the one in the ISO) with the different soundcard drivers I find there. Amongst other miscellaneous tweaks to prebuffer/blocksize etc. Nothing fixed the problem, some made it louder, quieter but none rendered the sound properly any more. :/