Jason_the_Iguana: However, on that same note, I would advice against specialising in Greatswords. Get a tower shield instead.
In this game, armour class is king and attack bonus queen. (If you're a fighter. Wizards say "meh" to both of them.) The shield always makes a huge difference, whether it's the +3 armour class from a shield at the first levels and the +6-7 AC from a shield at high levels. Not to mention that the shield can have extra magic properties, like elemental damage resistance.
Sword and Board has a small overall mechanical advantage, but it is more fun to do more damage and kill enemies faster, and it is situational.
But generally I subscribe to: "The best defense is a good offense" axiom.
Dead enemies do no damage. The sooner they are dead, the sooner they do no damage. Also helps cutting through enemy DR, which could tip even the mechanical advantage in favor of the big weapon, not just the fun advantage.
A Longsword with 18 str averages 8.5 dam/round.
A Greatsword with 18 str averages 13 dam/round.
Throw in DR 5 and you are in for a LONG fight using a shield. You are doing more than double damage with GS in this case.
That said, I always have multiple weapon sets (Two Handed/Weapon+Shield/Ranged).
My alternate Weapon/Shield, Usually has alternate damage type (Warhammer) that I only use when my HP are knocked down, and/or I need the alternate damage type.
I start every fight with my big weapon, and kill my enemies faster, and only switch if I need a breather (switch to shield, drink potion).
Basically use some common sense on when to switch but I see no reason to generally not favor the big, high damage weapon as the default choice, and only use shield when you really need a shield.
Playing the OC I remember the satisfaction after I switched to this method and you get one shot kills on Mobs, followed by cleave one shot kills. The fight is nearly over when you drop two in the opening round. Plus it is just so damn sweet when that happens.