The game starts but I can't click on anything. I can move the mouse pointer around the menu but selecting anything? Out of the question.

Anyone know any fixes for this?

I read about disabling movies and have tried that but no joy :(

Im a victim of this bug as well. It happens in the starting menus mainly the change resolution screen. If I change that my left mouse button will stop working. I have to leave resolution at 800x600 default and then it will still lock up my mouse buttons sometimes. Always in the startup menus.

Ive switched compatibility mode to Windows xp service pk2 and having better luck so far but still cant touch resolution settings without the issue popping back up.

Windows 10 z170 chipset.

Thanks man but that doesn't seem to fix it. Still can't go or do anything. :(

Clicking through the opening videos for Bioware and Floodgate solves it for me.

Oh, and this also forces the opening cinematic with the minotaur to play.

My mouse works, so that I can play the game, but the keyboard yields absolutely no response in game.

My problem was that my keyboard worked but the game wouldn't accept mouse input. After several hours of fussing and fuming I found a very simple solution. All I needed to do was press alt and shift at the same time in the game window after it loaded fully.

I'll list my computer specs in case that is relevant:

Chassis : Desktop
Mainboard : ASUS CROSSHAIR V FORMULA-Z
BIOS : AMI (OEM) 2201 03/23/2015

Processors
Processor : AMD FX(tm)-8350 Eight-Core Processor

Memory Module(s)
Memory Module : 4x G.Skill F3-2400C10-8GTX 8GB

Video System
Monitor/Panel : 2x ACR XG270HU
(2560x1440, 27.0")
Peripheral: HTC Vive
Video Adapter : 2x MSI VCX RX 580 8G GDDR5 256B PCIE

Storage Devices
AMD 4+0 Stripe/RAID0 (446.9GB, RAID, SCSI-4) : 447GB (C:) (E:) (F:)
Disk (17.2GB) : 16GB (D:)
Disk (7451.9GB) : 7452GB (G:)
ASUS BW-12B1ST a (SATA2x1, BD-RE, DVD+-RW, CD-RW) : N/A (H:)

Network Services
Network Adapter : Intel(R) 82583V Gigabit Network Connection (Ethernet, 1Gbps)

Operating System
Windows System : Microsoft Windows 10 Professional 1709 10.00.16299.64
Platform Compliance : x64

Input Devices
Keyboard : Logitech G510S
Mouse : Logitech G502 Proteus
Peripheral : Logitech G13 Gameboard

I have the same problem, I think. All of a sudden, the ground is no longer clickable. My characters only move when I click on an item or character (or doorway) that can be interacted with. They also do still move with the keys - but cannot be made to change direction (turn left or right). The bug has affected all saves so I can"t go back to an earlier point in the game (and I'm almost at act III so I've spent more than 30 hours on it).

I've tried all the fixes proposed here, but nothing works. Is there a patch to bring this game beyond version 1.23?