DCT: try going into the dosbox config for the game and go to the Soundblaster settings and set the IRQ from 7 to 5 and lower the cycles to 2000 it should help
silentgeargrandi: I'm a little bit of a greenhorn when it comes to that stuff. Might it be too much trouble for a step-by-step? I don't want to corrupt my game by accident.
Okay, go into your Larry 6 directory it should be c:\gog games\leisure suit larry\leisure suit larry 6\ now in this directory you should find a file called "dosbox_l6.conf" open this is notepad or similar program, now you should see a listing of a bunch of stuff like:
[dosbox]
language=
machine=svga_s3
captures=capture
memsize=16
scroll down till you see:
[cpu]
core=auto
cycles=max
cycleup=1000
cycledown=1000
now change the number on the line marked Cycles= from max to 20000 then scroll down again till you see
[sblaster]
sbtype=sb16
sbbase=220
irq=7
dma=1
hdma=5
mixer=true
oplmode=auto
oplrate=22050
now change the number on the line irq= from 7 to 5
then save, also no need to worry about ever "corrupting" your game as the settings in dosbox.conf's files only affect the Dosbox emulator and not the game itself.
if your still having issues with sounds just let us know here and myself or someone else will see what can be done