Update since there hasn't been much activity on this support page in a long while and for those of you who are still on the fence about this title
I am running I'76 GOG 2.0.0.17 under Win 7 Home Premium x64 on a Core 2 Duo with ATI Mobility Radeon HD3650. So far, the main game runs well using the default GOG launcher from the icon on the desktop. I have set all of the graphics settings to High. I found I had to leave the screen resolution at 640x480 max. I got the wobbly tires thing when I ran 1024x768 and I did not bother with anything lower than 640.
I have also run the game successfully by dragging a shortcut directly to I76.exe to the desktop, adding -glide to the command line and running in compatibility mode for Win95, again bumping all graphics options to max. I was unable to change the screen resolution.
I am only out to Scene 6 in the game, but so far, it seems to be working.
FYI: my game was set to Wimp difficulty. I am not sure if that is default or left over from my previous attempts to run the game.
Also running a PS3 Dualshock controller via USB using MotioninJoy Gampad tool drivers on PS3 mode pretty much all default. I did find I had to open up the PS3 Options and back out of them before my thumbsticks would map properly onto the axes.