Ueber: Has anyone testet Grim Dawn running in Wine? :)
Yes.
I am running it under wine-gaming-nine from the Arch User Repository. This is Wine-1.9.5-staging with some Gallium patches added in along with the regular wine-staging patches.
Here's the AppDB ebtry for Grim Dawn:
https://appdb.winehq.org/objectManager.php?sClass=version&iId=29162 I used the Nvidia tweaks (I changed my OpenGL settings to "Allow Flipping", the PowerMizer setting to "Prefer Maximum Performance"). I also edited my xorg.conf file and used the profile.sh tweak as listed in that AppDB entry. Since I am using wine-staging I also had to enable CSMT to fix the invisible characters issue.
Since I am running on slightly older hardware (Nvidia 560 Ti, 4 GB RAM) I am experiencing crashes on area transitions for some reason but the main game plays quite well with the default settings.
tl;dr it works but you may need to put some work into making the game work :)