IoriBranford: Yes, I'm one of those victims of Gothic 2's infamous "failure to launch" issue. (I suspect this is the fault of the typical design-centric RPG development focusing on the world and story while serious bugs and poor engineering decisions may be undiscovered or forgiven...but that's another thread.)
None of the proposed solutions have worked. Drivers up to date, no firewall, no antivirus, no Daemon Tools, no Internet, no unnecessary processes, but no go. Even an hour later, its only sign of activity is a process with 0% CPU and 16MB memory use.
The only possibility I can think of is that, because I simultaneously uninstalled the demo (which did run) and installed the full game, some critical registry entries are screwed. Numerous reinstalls have not fixed this; I may have to regedit my way in there and clean it myself.
Most infuriatingly, my netbook can run it fine, with Avast antivirus installed and running.

PDF: Maybe you have a problem with the Gothic VDFS program (the thing that launches before the game and try to "setup" your system for the game). There is a VDFS patch around, I think you can find link in other posts here.
You can try to launch the game directly by renaming "vdfs32e.exe" to anything else, and see what happens. Renaming the file is also a good trick even when the game runs correctly, because the thing keeps launching and wasting time uselessly at each game launch.
Hope it helps !

Ralackk: Have you tried changing your changing the sound hardware accelertion slider in dxdiag or even disabling your sound card via device manager to rule out sound card problems?