After using the Consumer Preview for the whole morning...
First thing first, lets start with the desktop. It features a much improved Windows Explorer. New versions of IE10 and WMP12 are also included. From what I saw, the interface feels a lot faster, and it is a lot more polished than Windows 7. The Ribbon is a nice addition for those with less technical knowledge, holding some commands that get used quite a lot. It is minimized by default, but when used, it allows you to do some things faster (revealing hidden files / folders now takes two clicks, instead of four (an example)).
IE10 on Desktop is amazingly fast. IE9 was very fast already, this is even better. It also feels like a lot more polish was put into it. I didn't saw much difference in the new build of Windows Media Player 12, the only thing I don't like about is that it doesn't open .MKV files, other than that, it is my primary media player. The performance of most other Desktop applications has been improved, they run faster than they did on 7.
The transition from Desktop to Metro requires a bit of figuring out. It is very easy to switch between the both, once you get a few hours of 'practice', try out different key combinations and mouse gestures.
Alt+F4 can be used to shut down a Metro app, but it is not necessary. Simply dragging the top edge of the app to the bottom will suspend it, in which it doesn't use much memory, and in a few minutes will close itself (afaik).
Windows key + Tab will list all Metro applications running, except the one you're currently using. Holding the Windows key after that can give you a fast way of navigating through Metro applications. I can't explain this correctly, but with Metro, now all applications are connected and share the data, making some things much easier do to.
Messaging application allows for Windows Live / Facebook chat. Bing's Weather and Finance apps are great.
Give it a few hours / day. You'll get the hang of it and do things much faster than with 7.
timppu: but when I entered e.g. Music Player, I didn't find any way to get back to the main screen from there.
Drag the top of every Metro application down to the bottom and it will get suspended. The app will save its state, and continue from where it was suspended once you start it again.