PC games will still always remain the haven for innovation and creativity, and where smaller but inventive teams can move something. Open architecture, free deployment and do-it-yourself distribution. Nothing can compete with that.
As for the big-budget titles, publishers really soured the PC market themselves. The PCs strong point are deep, complex games. What we get instead is ports of console-style games that people, well, would rather play on a console than on the PC.
Luckily there are many big developers and publishers still devoted to the PC platform, not just porting but also putting in some thought (I think Rockstar and BioWare are agreeable examples). If you know how to optimise and market them (i.e. not botch them with DRM), the PC is a big market. And there's always developers from Europe, where apparently Adventures and complex RPGs never died.