Weclock: The Witcher - TAGES (but it's actually very unintrusive, I was able to install and play my game w/o CD key).
TAGES is not uninstrusive at all. It installs hidden drivers without telling you and progressively disrupts your gameplay without any warnings if you don't activate the game properly and have the original media in the drive while playing. In fact, with the Witcher, it actually made it impossible to beat the game since the gameplay disruptions resulted in the disappearance of certain NPCs. They did fix it with an update to the TAGES system however.
As for other games with copy protection (just by going through my library):
Darkstar One - TAGES
Scrapland - StarForce
Freedom Force - SafeDisk
Freedom Force vs. The Third Reich - StarForce
KotOR - SecuROM (V5)
KotOR 2 - SecuROM (V5 initially, V7 after update)
Vampire Bloodlines - SafeDisk
Call of Duty and United Offensive - SafeDisk
Freelancer - SafeDisk
Tron 2.0 - SecuROM (V4)
Grand Theft Auto 3 - SafeDisk
Grand Theft Auto: Vice City - SecuROM (V4)
Advent Rising - SecuROM (V7)
TOCA Race Driver 3 - StarForce
Hitman 2 - SecuROM (V2)
Hitman Contracts - SecuROM (V5)
The rest of my games, I'm not as sure about what they have for DRM. If I can figure it out, I'll add them.