Andy_Panthro: Yes, you do notice the hands. There are one or two NPCs with oddly proportioned heads also, which stand out rather awkwardly. In one case, there was a mage in one of the DLC that looked like he had a case of microcephaly.
One thing that annoys me for no good reason is the clipping of certain armours (the templar one springs to mind) where the pauldrons clip into the chest. Must be a touch painful, but it happens often in conversation.
The thing with the hands is, once you notice it, there's no way to stop paying attention to it. Weird...
The clipping can be annoying, yes. I'm playing an elf, and at some point i equipped a two handed sword, and while walking around, the legs of my elf would clipp the tip of the sword with each step. Ouch!
Also, some weapons seem to float in mid air in the sense that there doesn't seem to be anything attaching them to the back of the character's armor.
But the VA, dialogues, characters and story make up for those little oddities so far ;)