HereForTheBeer: Geez, I hope I didn't lead you on a bad path. I've used it on two desktops and three laptops, including two from-scratch Windows re-installations, and it's been a lifesaver. If it screws up on you, just use the reg back-up it makes and go the manual update route.
No serious problems here. Having read a bit more, Slimware may only handle Windows driver versions, and so it may be attempting to replace more recent drivers I have installed from the original manufacturer in some cases.
My USB drivers have gone to hell, and as my keyboard and mouse are USB, I'm finding it a mess to completely replace them as my ability to interact with the computer drops during the process. I saw your post and was hopeful it'd solve the problem.
Maybe I was just unlucky with the drivers I selected to update.