misteryo: Skyrim - new game with this mod list:
I have no graphical enhancements, so my performance shouldn't suffer at all, and that will nice for a change. I think I've changed everything I want to change. Maybe I'll play the main quest through this time... maybe.
I know you said you've modded it about as much as you want, but I do recommend you check out the Interesting NPCs mod. It adds a ton of new NPCs (around a hundred I believe) to Skyrim, each of them fully voiced and many of them offer quests, including some that offer full fledged several hour long questlines.
While the audio quality of some of the new NPCs can be a bit iffy, they're mostly well voiced, and most of them are written far better than the vanilla NPCs. The full fledged questlines are (in my experience) also much better than Skyrim's vanilla quests. Quest dialogue (and actions) can change based on your interaction with the NPCs and your general actions around Skyrim, and many of the quests actually tie together.
I can't recommend Interesting NPCs enough, if I could only choose one mod to use, that would be the one I would choose.