HypersomniacLive: Do you allow them on a permanent basis? If yes, this is what makes the difference. I allow them only temporary, even those that I "trust".
When I am troubleshooting a new site, if it requires cookies (usually meaning a login session), I allow that permanently through for the site because not doing so gives no benefit and only causes login headaches. I may do it "all" or "session-only" depending on the website and how much I trust them and how often I'm likely to log in there however.
For RequestPolicy Continued, and NoScript I normally only allow temporary at first until I can confirm what the minimal amount of domains/subdomains are needed through experimentation to allow for proper site operation. Once I have determined the minimum set, I flush the temporary rules and make permanent rules for the site if it is a site like GOG that I'll be using all of the time or on some kind of regular basis. If it is a one-off view of some random site then I normally only use temporary.
My personal goal is to greatly reduce the attack surface of potentially malicious content, spyware/tracking content, consumer-unfriendly content, resource wasting content, etc. while maintaining a balance of convenience for the sites that I frequent the most.