I ran this game with Wine today, and was somewhat surprised it didn't have a post yet:
Game: Geneforge 1
Installer MD5: 99143f9144e083bf8d207f92f5182dd7 setup_geneforge_2.1.0.7.exe
WineHQAppDB link: https://appdb.winehq.org/objectManager.php?sClass=application&iId=2083 Distro: Linux MInt 18.1 (based on Ubuntu 16.04) 64-bit
Kernel version: 4.4.0-21-generic x86_64 (64 bit)
Graphics card: Intel Broadwell-U Integrated Graphics
Graphics driver: intel (unloaded: fbdev,vesa)
GLX Renderer: Mesa DRI Intel Broadwell GT1
GLX Version: 3.0 Mesa 11.2.0
Wine version tested: 2.0-staging(x86) via PlayOnLinux 4.2.10
Additional notes: Launch from geneforge.exe. When the game runs, it asks whether to change the resolution, as the original game had a small resolution (the dialog it shows looks like a Wine one, so it probably shows the same under Windows too). Clicking "Change Resolution (Recommended)" works as desired, as the game fullscreens seamlessly and when quitting it returns to desktop seamlessly as well - I presume "Always change resolution" will have this desired result as well. It doesn't have widescreen of course, but that's to be expected, and at any rate it scales pretty well so the letters aren't small at all.
How well does it run: Perfect so far (played for about half an hour, not as a single session). Save/loads as expected, graphics/sound e.t.c all work great.
Sidenote: When I initially tried with Wine 1.8, the right side of text in the popup boxes was cut off slightly, but version 2.0 doesn't present that problem.