I'll re-test & update the Van Helsing report when PlayOnLinux adds the latest versions of Wine/Wine Staging

Game: Space Run: Fast and Safe Delivery
Installer's MD5: e370f25708f12ef1916400a25c2c4e9c setup_space_run_2.1.0.2.exe

WineHQ AppDB link: https://appdb.winehq.org/objectManager.php?sClass=version&iId=32885&iTestingId=93669

Distro: Linux Mint 18 Sarah x86_64
Kernel: 4.4.0-45-generic
Card: GeForce GT 330M
OpenGL Renderer: GeForce GT 330M/PCIe/SSE2
OpenGL Version: 3.3.0 NVIDIA 340.96
Wine version: wine-1.9.21 (wine-devel amd64).

Install notes: Install and play.

How well does it run: Perfectly.

Details: I've set a 32-bit prefix (WINEARCH=win32). Windows version is set to XP.

Game: The Incredible Adventures of Van Helsing: Final Cut
Installer's MD5: 7ca973cd729b14374c1b850ca2f9daed setup_van_helsing_final_cut_2.0.0.5-1.bin
06fdbebee3bb0c2b25641a5c8413d9af setup_van_helsing_final_cut_2.0.0.5-2.bin
160967217ba0e1adc2a5864d3686c891 setup_van_helsing_final_cut_2.0.0.5-3.bin
eaa65b2aef558d97e9c36ae07c1fc615 setup_van_helsing_final_cut_2.0.0.5-4.bin
1bebc99131392f818b4c776f4ca920a7 setup_van_helsing_final_cut_2.0.0.5-5.bin
00c2d12a35211d7261ef64463a19b29b setup_van_helsing_final_cut_2.0.0.5.exe

Distro: Linux Mint 18 Sarah x86_64
Kernel: 4.4.0-45-generic
Card: GeForce GT 330M
OpenGL Renderer: GeForce GT 330M/PCIe/SSE2
OpenGL Version: 3.3.0 NVIDIA 340.96
Wine version: wine-1.9.21 (wine-devel amd64).

Install notes: Install and play.

How well does it run: Perfectly.

Details: I've set a 32-bit prefix (WINEARCH=win32). Windows version is set to XP. OpenGL renderer is used in game.

The game actually installs two Windows native libraries without asking. There is nothing to be added by the user after the installation has finished though.

damn, back to another weekend of playing KSP then ;)

I've updated the Aquanox and Quake 3 Gold summaries. Turns out that the cropped resolution was Compton's fault.

Game: Painkiller: Overdose
Installer MD5s:
d347709b6f89f8263b1a1ebbf46e1214 setup_painkiller_overdose_2.0.0.2-1.bin
0ac8e94ceb82bec04ee7a11051911b0b setup_painkiller_overdose_2.0.0.2.exe
WineHQ AppDB link: https://appdb.winehq.org/objectManager.php?sClass=application&iId=6005
CodeWeavers link: https://www.codeweavers.com/compatibility/crossover/painkiller-overdose

Distro: Linux Mint 18 Cinnamon 64-bit
Kernel version: 4.4.0-45
Graphics card: Nvidia GeForce GTX 750Ti
Graphics driver & version: Proprietary 370.28
Wine version(s) tested: Wine Staging 1.9.20 via PlayOnLinux, CrossOver 15.3.1

Install notes: Requires d3dx9_35 (install DirectX 9 Modern in CrossOver) - *might* not be necessary as of Wine 1.9.21 (see vanchann's report) but 1.9.21 was not available via PlayOnLinux when I tested this.
If using CrossOver use a Win7 bottle, otherwise it refuses to run with the error: "Painkiller Overdose requires at least Service Pack 2." (this also happens with regular Wine but not Wine Staging)
If using PlayOnLinux, run the game from/create a shortcut for "Overdose.exe"
How well does it run: Perfect
Details: Have only tested for a very short time but it seems to run perfectly. Tested with virtual desktop and CSMT enabled.

Thanks for this additional report.
Looks like we have covered many setups this way. I added a link to your report too. :-)

Game: Aquanox 2 - Revelation
Installer MD5: 31c0361ca6310771428474099850ee87 setup_aquanox2_revelation_2.0.0.3.exe
WineHQ AppDB link: https://appdb.winehq.org/objectManager.php?sClass=application&iId=7348
CodeWeavers link: https://www.codeweavers.com/compatibility/crossover/aquanox-2-revelation
Distro: Antergos 64-bit
Kernel version: 4.8.4-1 ARCH
Graphics card: Nvidia GeForce GT240M
Graphics driver & version: Proprietary 340.98-2
Wine version(s) tested: Wine Staging 1.9.21 via PlayOnLinux

Install notes: None
How well does it run: Perfect
Details:
*No issues have been found using CSMT or using the virtual desktop
*Instant fight and Campaign mode were tested, no issues have been found.

Game: Lords Of The Realm 2
Installer MD5: 1e4a4141055365be37fc550c4d83b4a9 setup_lords_of_the_realm2_2.1.0.32.exe
WineHQ AppDB link: https://appdb.winehq.org/objectManager.php?sClass=application&iId=2165
CodeWeavers link: https://www.codeweavers.com/compatibility/crossover/lords-of-the-realm-2
Distro: Antergos 64-bit
Kernel version: 4.8.4-1 ZEN
Graphics card: Nvidia GeForce GT240M
Graphics driver & version: Proprietary 340.98-2
Wine version(s) tested: Wine Staging 1.9.21 via PlayOnLinux

Install notes: None
How well does it run: Perfect
Details:
*Played the skirmish and the custom game. No issues have been found.

Meant to ask earlier, did you need to set MouseWarpOverride at all?

I've actually didn't checked that. All i did was install the game and run. I haven't found any problems, but since ya mentioned that command i've remembered that AquaNox has some mouse look issue related to the DPI and/or it's polling rate. I've been using the Microsoft Wireless Mouse for this test. I'll check it with my SteelSeries Rival 100 and Razer Abyssus. I will edit this post for the results.

EDIT: I've checked the game with SteelSeries Rival 100 set at 2000 DPI with 1000Hz polling rate. There were no mouse related issues at all.

*poke*

Waiting for reports on Crysis. Does CSMT have any remarkable effect on performance? Graphical glitches with or without it? How is it with glsl disabled?

Crysis seems to mostly run well with CSMT but there's some glitching with water effects (flickering etc). Setting r_HDRRendering=0 fixes the flickering but introduces some other issues & ugliness with the water effects instead.

Well great. I just got around to testing it and water is glitched with or without CSMT. I can't tell if there's any remarkable difference in performance. Any idea how to show framerate in the island GPU benchmark?