Thanks again.

I tried to run the game. There weren't HLSL shader parsing errors (or I missed them, but I've checked again and again). Then I tried to set all dlls to default and then reinstall the suggested libraries with the same results. Maybe more things than those intended, were set to default.

I'll check again later using a clean prefix.

Unfortunately the problem persists.

I tried with a clean prefix adding libraries one by one, with nothing got fixed. I think I should forget playing the game for now. Alternatively I could downgrade Wine port to the working version and recompile it, but that could create more incompatibilities than it solves.

Thanks for your time and suggestions.

Game: Titan Quest - Anniversary Edition
Installer MD5s:
e735387eedf6e35cc964318d44b89b8f setup_titan_quest_anniversary_edition_2.3.0.5-1.bin
63670b4678da760e54d677e579e7e914 setup_titan_quest_anniversary_edition_2.3.0.5-2.bin
ad4144e57a9e300f5a88cfe6b32395f8 setup_titan_quest_anniversary_edition_2.3.0.5.exe
WineHQ AppDB link: https://appdb.winehq.org/objectManager.php?sClass=version&iId=34206

Distro: Linux Mint 18 Cinnamon 64-bit
Kernel version: 4.4.0-36
Graphics card: Nvidia GeForce GTX 750Ti
Graphics driver & version: Proprietary 370.23
Wine version(s) tested: Wine Staging 1.9.18 via PlayOnLinux

Install notes: When it asks, let it install the Visual C++ redistributables
Run the game from/create a shortcut for "Tq.exe"
Set registry key HKCU/Software/Wine/Direct3D/CheckFloatConstants to "enabled"
How well does it run: Perfect
Details: Have played through much of the game, all works perfectly so far. Tested with virtual desktop and CSMT enabled.

the clouds look like those I've seen on youtube. did a quick youtube vid: https://youtu.be/7A8wLavv-i0

Thanks adam! I was already wondering if someone tested it :)
The game is running with no problems. My only trouble is with creating a shortcut to tq.exe. I have tried to create a launcher with the path to it like: wine "(...)Tq.exe" but it does not work. Do you have a suggestion? Thanks. I'm in Mint 18.

Updates are pushed back another 12 hours at least. Flash drive flaked out on me. Simpler for me to resync when I'm back at the other machine.

Nice, I was going to ask about this one.
They can vary but general idea is something like this:

Thanks for all your efforts Judas.

I've tried to launch a few games this morning as I've updated from 1.9.13 to 1.9.17 the last weekend. Many games I tried like Blackguards 2, Divinity Original Sin (classic version), Technobabylon, Overlord are broken now. Other games like Age of Wonders 3 and Van Helsing Final Cut keep running fine.

I think the problem is specific to Wine running on FreeBSD. This view has been reinforced by GOG's new addition Titan Quest failing today, while it runs on Linux as adamhm reported.

Maybe I should consider compiling/installing Wine on Linux again. I have relatively limited disk space there though.

EDIT: Thanks adamhm for your report!

Are you using packages? I would be curious what you see if you built the port instead, wine configure output in particular.

Thanks for the video, they seem to me moving faster than they should be. However, the only way to be sure is to play it till scene 5 (big jump) and see if it can be completed. When the speed is broken, this bit is impossible to do.

Did you patch the game to make it run? I've just tried running it in wine 1.9.17 and I still get the crash at the start (which is because of this bug: Bug 21924). With the patch suggested in the discussion the game works too fast.