eiii: Maybe the anniversary edition is not as optimized as the old retail version, requires a faster PC and the minimal system requirements have not been adjusted for it? So my PC just would be too slow to play it. :(
I mean one of the listed features is improved performance & stability, so I find it kinda weird that it'd require higher specs. Of course it's possible that they've made a blunder at some point along the way.
I kinda doubt your CPU is the issue, unless it's something to do with an ISA extension. In fact I'm pretty sure I tested titan quest at some point on a system with integrated intel graphics and one of these low power (U postfix) Core i chips that you find in thin ultrabooks and slim fanless PCs. These aren't remarkably faster than a 3.1 GHz C2D.
EDIT: Sigh, I can't see anything in the main menu. Splash & intro cinematic plays and then it's black screen time.
EDIT2: Eh right, this was one of these games that doesn't like having 8GB of video memory.. set VideoMemorySize to 512 and I see the menu.
EDIT3: I played for a few hours last night, and the game ran just fine. I think there might've been a few little lag spikes at some point, something that could've been annoying in a very tough fight but I think these happened around transition zones.