FYI, they have the new WineHQ build server up. It's not quite live yet and I believe there will be some minor changes tomorrow. They are now packaging stable builds as well as keeping older builds, AFAICT, (going forward).

I guess you also don't acknowledge the muntdefems' signal?

Done.

My system openal is setup with hrtf for positional audio with headphones. With wine using its builtin openal, this just works.

I suppose that it would be possible to do the same with the windows-native openal, but it requires a new enough openal-soft library, hrtf data files, some extra configuration that I'm not at all sure how to do in windows, and wine probably complicates the setup further. I hope they're not getting rid of the builtin openal support, although I guess there are not really that many games that use it.

Would you happen to know how GMDx runs in Wine? All this talk of Revision makes me want to attempt GMDx again, but I'm not sure because it appears to use it's own renderer.

I haven't tried that

Arch, RX480, metro does not run.
I tried GMDX around the time Revision first released (on Steam..) and it ran just fine, although I can't remember whether I had to do any tweaking or not.

The PlayOnLinux script installs POL_Install_d3dx9_36 and Set the OS to winxp. Look here
https://www.playonlinux.com/en/app-1278-GOGcom__Star_Wolves.html

Thank you! But that's not it. I've already figured it out: you need to launch the game from its installation directory (or specify Path in the "desktop" launch file). Otherwise the game can not find some (but not all!) of its resources, among which are fonts and video files (1C logo and such).

As it turned out for this game there is no need to use Winetricks or add DirectX files at all! (I've tested on a separate clean prefix).

Saints Row 4 ?

(n.b. Apparently there are native Linux versions for the Saints Row games on Steam, but not at GOG. That's disappointing. It would be good to know whether any steps are being taken to remedy that?)

Not native, but there are eON based ports. Don't bother if you have an AMD CPU though.

So does everything work on Wine :D

Has anyone tried Pathologic recently? There's a sale and I'm intrigued, but the wine appdb doesn't look promising.

No.

I run an AMD FX CPU and a Radeon 270X, played through the Linux release of Gat out of Hell on Arch without any problems whatsoever and wonder why I shouldn't have bothered doing that.

I've been playing Pathologic with wine 2.0+ without problems. Linux Mint 64 bits 18.1.