Just the other day, I saw somebody playing the Virtual Boy version of Tetris.

The sound that plays when the stack is almost at the top is obnoxious.

Then again, danger beeps do tend to be annoying, but this case is particularly bad.

I could also mention one effect in the Baldur's Gate series; when you try to leave an area when not everybody is nearby, there's the voice acted system message "You must gather your party before venturing forth." Why did they choose to voice act *that* line, particularly when it's easy for it to be triggered repeatedly in a short time. (Then again, I personally think the rule shouldn't have been there in the first place; the game would have been better if going to the next area only required one character to reach the edge of the map.)

They included it in PoE too :-)

But only if you clicked the "leave map" icon at least twice, without other input in between. This way you rarely hear it.

I SPEEL MY DRINK! (one of the Russian sailors in Deus Ex).