While far from having played "all" adventures, I have played my share and graphical adventures were my favorite kind of game as a kid. I have my opinions on a handful of titles, many of which have been mentioned here, and a few of which I differ in from what most people here say.
First of all, do NOT go for
Chains of Satinav. It's not because it isn't a good game, it is actually great, but its engine is poorly coded and as a result you'll have hiccups whenever you change scenarios or move from a place to another. If adventure games test your patience already as they are, this one will have you tearing your hair out simply due to how poorly optimized it is. It's a great game otherwise, but I can't recommend it to you based on what you said.
If you want a Lucas Arts game, go for
Grim Fandango. It's easily the masterpiece of Lucas' adventure games, with a storyline that's both funny and serious at the same time. You'll laugh, but you'll also find yourself invested on what's going on and the overall difficulty isn't too high.
If you go for
Legend of Kyrandia, skip the first game. Though a great series, the first game is too much of a guide-dang-it where you're given a ridiculous amount of items that are useless except for one or two you're expected to hold onto for long periods of time with no clue whatsoever. The second and third games remedy this, and I recall loving both of those.
If you want a story and setting above everything, go for
Syberia. Out of all the adventure games I have played this one is the game that has dragged me in the most, simply because the setting is beautiful. It's not a comedy, so you'll be genuinely invested in the narrative as opposed to wondering what crazy hijinks the protagonist will be up to next.
I don't consider
Telltale Games to be makers of graphical adventures these days. I feel their games nowadays are interactive movies where your input is severely limited and most "puzzles" are absurdly easy. However, if you feel like you MUST see what's in it,
Tales From The Borderlands shouldn't disappoint: It's funny, it's witty, and it has an overall pretty good storyline. Alternately,
The Wolf Among Us is also pretty good. Or, if you want real adventure games, the three
Sam & Max telltalle seasons are great, particularly the third one. Stay away from
Tales of Monkey Island, however, since it's not really a good series and the episodic format really makes the Monkey Island setting suffer.
I found
The Longest Journey to be quite good, but it's easily the wordiest adventure game I have ever played: You'll have to read, a lot, and sometimes you might find yourself wishing for conversations to be over so you can get back to pointing and clicking.
Last, but not least, if you want comedy I can't recommend
Simon the Sorcerer enough, along with
Day of the Tentacle. Also, as mentioned by many,
Deponia manages to capture that Monkey Island vibe with a useless, widely hated protagonist who's not so much of a lovable jerk as he's simply an idiot. It works well, however.
As for more classic games, I'll agree that the
Sierra games are mostly outdated and finishing them without a guide can be difficult, and that's without mentioning the outdated graphics. However, games like
King's Quest have been remade by independent studios, completely overhauling the graphics and adding a new difficulty setting where you can't lose the game (ie, all puzzles that could end up in an unwinnable state have been fixed). You can get those remakes in the
AGD Interactive Website.
Last, I'll take a minute and add one game I haven't seen around in the thread:
The Cave is a cool, witty graphical adventure with simplistic design from the creator of Maniac Mansion. It is well worth playing it, even when it doesn't quite play like other adventures.