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Phantasmagoria is a horror game about a relationship turning sour really fast and out of the blue. There's definitely some metaphor about mental health in there somewhere
Fran Bow
Psychonauts is all about dealing with mental health issues, albeit in a completely abstract way that rarely touches on reality.
The Long Reach - is heavy on psychological horror. Characters losing touch with reality, hallucinating, going insane. An experiment on human psyche goes out of hand story.
The Oblivion expansion has a whole world themed around mental health. If you keep an eye out you can identify symptoms of certain disorders. In Mass Effect, eezo experiments can cause all sorts of psychiatric issues. There's a few missions that revolve around this theme.
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samuraigaiden: Phantasmagoria is a horror game about a relationship turning sour really fast and out of the blue. There's definitely some metaphor about mental health in there somewhere
I'd say the first one deals more with demonic possession. One could argue that that's some kind of metaphor, but it doesn't really fit in anywhere. The second Phantasmagoria game does, though. Isn't the main character on therapy?


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J Lo: The Oblivion expansion has a whole world themed around mental health. If you keep an eye out you can identify symptoms of certain disorders.
I did not know this, I have the game in my library, I need to check that out! Thanks :-)
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Tokyo_Bunny_8990: Silent Hill 2 is quite famous.
Hard to find but Eternal Darkness has a sanity meter that causes negative effects when it gets too low (saves deleted message, blue screen of death, etc).
Wait, if the sanity gets too low, the game deletes your saved games? What an awful mechanic!
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Chasmancer: and another point and click adventure about a girl offing her parents, getting locked up and trying to escape the institution, that I also can't remember the name of.
If you want to replay that, too, that sounds like Fran Bow.
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Inkshock: I'm looking for games that somehow deal with or depict psychiatry and mental health. Do you guys know of any that you can recommend?

I already own Hellblade, Sanitarium, The White Door, Suicide of Rachel Foster (and maybe some I can't remember off the top of my head) and I have a bunch already on my wantlist, but I'm always looking for more.
I am not familiar with any of the games you mention, but I can point you to This war of mine-it deals with decisions that can affect the mental health of the characters. It is also an excellent game.

https://www.gog.com/en/game/this_war_of_mine
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samuraigaiden: Phantasmagoria is a horror game about a relationship turning sour really fast and out of the blue. There's definitely some metaphor about mental health in there somewhere
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Inkshock: I'd say the first one deals more with demonic possession. One could argue that that's some kind of metaphor, but it doesn't really fit in anywhere. The second Phantasmagoria game does, though. Isn't the main character on therapy?
In the first one, the woman has all the tools to just leave but she decides to stick around while her spouse behaves worse and worse - until he starts trying to kill her. There are many layers to that plot
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Tokyo_Bunny_8990: Silent Hill 2 is quite famous.
Hard to find but Eternal Darkness has a sanity meter that causes negative effects when it gets too low (saves deleted message, blue screen of death, etc).
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Maxvorstadt: Wait, if the sanity gets too low, the game deletes your saved games? What an awful mechanic!
Does it *actually* delete your saves, or does it only display a message saying that your saves have been deleted? There's a big difference here.

There's one other game I can think of that claims to have deleted your save, but doesn't actually do so. (I don't think that game deals with mental health issues, however.)
Didn't play it, but remember reading that Fahrenheit / Indigo Prophecy also measured characters' mental state, ranging between various levels of depression, didn't it?
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Chasmancer: There was also an old, increasingly surrealistic and macabre point and click asylum adventure that I would recommend and love to replay if I could remember its name to begin with
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Inkshock: Do you mean Sanitarium?
No, I remember playing Sanitarium, it's isometric, uses sprites, and not quite messed up enough. That one was all hand-drawn, classic sideways point and click with only but few first-person scenes.
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Chasmancer: and another point and click adventure about a girl offing her parents, getting locked up and trying to escape the institution, that I also can't remember the name of.
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lolplatypus: If you want to replay that, too, that sounds like Fran Bow.
Also not it, that one didn't really have any drug-induced fantastic creatures to speak of. But this one is a fairly good suggestion in its own right, and I haven't played it yet so might be even better, thank you.
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Maxvorstadt: Wait, if the sanity gets too low, the game deletes your saved games? What an awful mechanic!
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dtgreene: Does it *actually* delete your saves, or does it only display a message saying that your saves have been deleted? There's a big difference here.

There's one other game I can think of that claims to have deleted your save, but doesn't actually do so. (I don't think that game deals with mental health issues, however.)
No your game wont be deleted. Its just a mind screw that makes you think the game glitched by saying you confirmed to delete your game and you do (although it doesnt really happen) along with other such effects.
I forgot Ether One.