Traditional card games were never really my thing. When I think of card games, my first thought is usually Magic the Gathering. I haven't actually played it in ages, and even back when I did it was with older, mostly common cards bought in bulk. It's a great game, but trying to stay current with it would require an insane amount of money and dedication to keep abreast of the new rules.
Timboli: Many games I eventually grew tired of ...
Monopoly comes to mind and
Risk.
BreOl72: Both games carry the risk
(no pun intended) to "overstay their welcome" on the table.
They most often simply drag on too long to stay funny and entertaining.
When I was a kid I used to really like Risk, but I think it was more the appeal of playing with the cool little armies than the game itself, which is honestly not very good and way too random.
My favorite board game definitely used to be Talisman. For a fantasy nerd it was just the best.
I still love board games in general, and fortuantely there are many fantastic new games these days - Inis, Lords of Waterdeep, Everdell, Cyclades, The King is Dead and many more. Unfortunately getting people together to play them gets harder and harder.
That said, I'm not too fond of the trend that got strong with Kickstarter, of making board games ever more elaborate, with a shitload of cool looking miniatures and other elements, basically stuff that looks great on the photos and helps inflate the price (and overcomplicates the game) beyond reason.