I like to use unusual setups as well, particularly when they actually work.
For example, mage tanks: Not viable in most games (because mages have low HP and defense), but there exist games where it works. Here are 2 examples that I am aware of:
Baldur's Gate 2: Create a mage or sorcerer (sorcerers are better if you have already decided which spells you like to use) and give her Mirror Image, Stoneskin, and Protection from Magic Weapons. She is now difficult to kill with physical attacks.
Star Ocean 3: I haven't played this game (though I own it), and this setup is only available late game, but there is a way to turn Sophia into a tank. First, there is an ability that converts HP damage to MP damage, making her low HP irrelevant. (For those unfamiliar with the game, some attacks do MP damage, and having MP reduced to 0 causes death.) Add to that an ability that boosts max MP by 40% and she can tank hits that would normally do 99999 HP damage. Create a weapon for her that regenerates MP (and the regeneration is percentage based, so high max MP increases the regen) and you now have a character who is very difficult for the enemy to kill, and she's a *mage*, of all things.