jared1986: my windows updated yesterday and ever since my gog games wont run...help????
Check DirectPlay, as suggested above. If that doesn't help and you're using Galaxy, try "verify/repair" from "manage installation". Otherwise re-install the game from the installer.
Major updates with Win 10 are in fact "in place reinstalls". They often kill important settings, third party dependencies and registry entries. We have the same problem at work, after every major Windows update half our stuff we need to work needs to be repaired...
I consider writing MS a hefty email with many f-words every time... I just fear it won't help.