When I was playing this, I surprised myself that I don't really mind the random intereaction with strangers. You can pretty much only meet them at one specific place. If you do, you can just wave your hand and then continue with your business. And I don't know of any way to screw anyone's game without their consent, all interactions are very limited. Only few gestures and gifting. One of those strangers really boosted my game at the start: I was gifted 4 fusion ignitors if I remember correctly (then container bug duplicated them to 8). Huge money for someone still struggling with inventory space and the game basics. I don't remember the name, I only noticed the gift some time after they were gone.
I think having shared universe with other platforms can be a good thing. This is one of the games that ages like wine. It was released 2 or 3 years too early, but they more than made up for the mistake.
schoolruler: I have not checked or tired yet, but can GOG users play with Steam users?
Based on the changelog, this is exactly how it should work. GOG users should display with GOG icon, other platforms will have controller icon. But I have yet to test it myself (kinda busy with KC:D now, but I'll find a few hours to revisit this, I still have to test the "new" mech too - I was one tech module too short to buy it when they released the update).