Navagon: It may have been improved since I last used it but I still wouldn't recommend touching Defraggler with a bargepole. After I first used it all my PSD and 7zip files were corrupted.
I ran a thorough defrag once using UltimateDefrag Free Edition.....NEVER AGAIN. It corrupted several OS directories when I run it before boot to defrag the OS/unmovable files as well. Had to reinstall windows.
EDIT: Just noticed that my pc has been defragging every week without me knowing. I wonder if that's why my old HDDs started corrupting after several months of use. Someone DID say a bit back that constant defragging ruins HDDs lifespans after all.
I shut the auto defrag off for now.....better to be safe than sorry.