Half-hearted resource drain systems. If they don't connect to the rest of the game in an intuitive way, then they are simply time wasters. Looking at you, Deadly Premonition.
Oh, and an uncommon but very nasty anti-feature...in Deadly Premonition: When replaying a chapter, you cannot save until you complete it. Not even auto-saving. As such, you have to complete everything you want in a single session, without something forcing you to quit. That was the final straw for me, when I lost a bunch of completed side quests and loot when Deadly Premonition crashed...
I am playing a game where you can learn weapon techniques by using the appropriate weapon. These techniques are unlocked by skill level and luck. The latter is a major issue, as you never know when it would happen. Literally fought over 100 battles with the same weapon without anything happening. In my opinion, games should be rigged so that bad luck doesn't get in the way of progression.
Oh, another issue with Deadly Premonition. Whenever you pick up an item, the game will stop and switch to a different screen so that you can see the object in detail. The problem here is that this happens ALL the time. It gets old very quickly, and wastes a great deal of time.