babark: If they ARE interesting enough that it makes sense to have them separate, then do that!
How would an interesting shop look like though? What would make it interesting?
With a little bit of effort I might still be able to imagine that the first time visit to a shop could be fun, but once that novelty wears off and you have to return there again and again to sell your stuff or buy something, on the gameplay side it becomes more and more tedious and unnecessarily time-consuming to have to run to and fro between several different shops.
I guess there'd have to be new developments each time you visit a shop in order to counter that. Like, IIRC, the shopkeeper of the magic shop in Shadowrun Dragonfall was an important NPC at the same time and able to give you advice, teach you something new or something like that, if you talked to them at different times, so visiting the shop could be interesting for other reasons than just shopping. But as soon as they don't have anything new and noteworthy to say anymore, it's back to being a waste of time in terms of gameplay mechanics.