neumi5694: Edit: Audio: I hate it, when retro games use early NES and the megadrive for music reference, they were just the worst.
Once more I have to mention the Amiga (4 hardware wave channels, it was possible to premix sounds on the CPU, resulting in the famous 7 channels sound of Turrican2), but also the Atari ST and even a SNES could sound good, if you got the right musician / programmer to work on it.
Thing is, I actually like the NES sound when it comes to music. It helps, in particular, that the NES is simply not capable of producing the sounds that give me headaches.
On the other hand, the sega genesis sound chip (what you're calling "megadrive", I assume) I don't like that much. I don't like its much harsher tones, and the sounds it seems to be best at are the ones that tend to give me headaches.
There's also the fact that music quality can vary from game to game, depending on how well (or poorly) the developers understand the sound chip.
For example, with the Phantasy Star series:
* PS1: (On the Sega Master System) The music here is decent, though there's the issue that the SMS sound chip sounds like a less capable version of the NES sound chip.
* PS2: The music just doesn't do anything for me.
* PS3: Some of the music is wonderfully composed. Unfortunately, most of it poorly utilizes the sound chop. For example, the title screen music has what sound like loud banging on bells, with a quiet melody that you can't really hear, and the theme for that one Layan town has a nice round that you can't really hear the second part of. (On the other hand, the music for the first part of the final dungeon actually works rather well.)
* PS4: This game actually makes good use of the sound chip, and aside from the occasional track that could give me headaches, actually works rather well. In particular, the first world map's overworld theme manages to work quite well, and is one of the rare times that a Sega Genesis game's music has a woodwind-like sound. (Well, the fantasia game on the Genesis, while it may not be the best game, does somewhat imitate a woodwind in one of its tracks, but it's not the instrument that most people think of when they hear the term "woodwind".)
mqstout: Graphics and sound don't really have cut-offs for me. It's all about the experience: controls and input, menus and play. Readability (or rather lack of) has a big impact for me.
Example:
Loop Hero tried really hard to make me avoid the game. Terrible text, low-contrast text, unrecognizable icons. It's nothing to do with the palette itself, but how they used it.
There's also issues when the colors are too similar, like with red versus green koopas in Super Mario Bros. on the NES. (I consider this an accessibility issue, and there are other games with this sort of issue, like that one Bomberman falling block puzzle game (except the Virtual Boy version) and Guacamelee!.)