I'm not very familiar with Wine etc., but have been playing all Windows games under Linux Mint (21.2 at the moment) for a while now. I use the 'Bottles' tool for this. https://usebottles.com/

In this Fallout 4 ran for me without any problems in the standard gaming environment.

If you don't want to try this wonderful tool for lazy people like me - maybe following settings are useful to you:

Runner: soda-7.0-9
DXVK: dxvk-2.2
VKD3D: vkd3d-proton-2.9

THX for the help. I'm new in gaming under linux.
And only made an account here in the past for the cyberpunk goodies.
Came back to buy imperium galactica 2 cause my disc broke, saw it was also for linux.
But bought Fallout 4 and SSE first.

Trying to make this game run, is like a whole new modding experience.

Install Lutris and use/install Glorious Eggroll (aka wine-ge-8-25-x86_64) to play it. Won't be any different than Windows.

Matter of fact, Glorious Eggroll will play pretty much any Windows game,

You don't want to manage all the Wine prefixes yourself. That is a pain. Let Lutris make as many Windows sandboxes as you want.

https://lutris.net/

Note another reason to run Lutris is the ability to tweak things on the fly easily, like adding anti cheat capability for some online games, to FSR support or disabling FSR support, being able to run multiple runner to find one that works best (mostly for older games), being able to add 3dfx Voodoo support for older games with a slick of a switch, adding or removing game monitoring tools like MangoHUD that you have seen in many an only video, adding DLL overrides, running Winetricks on the sandbox to say like install Windows Corefonts for games that seem to be missing text, you can force a certain number of CPU cores, If you have a laptop with both Intel and NVidia in it, you can force the NVidia with NVidia Prime support, you can get at the Wine control panel and do things like enable or disable joysticks, or get at the Wine configuration and see if quad or 5.1 sound is enabled... This list is endless. It is the defacto standard for running anything Windows...

One last thing, it will do any platform you can imagine... Not just Windows. Here is what mine currently looks like. I have some C64 and Amiga and MS-DOS going on in here too (See attached).

Hope it helps.

Forgot to mention, I haven't tried Bottles yet. Lutris works out of the box if you don't use their website for scripts. Most of their scripts work, but some are problematic, so just install using a local installer from GoG and all will be well.

I don't think I would switch to Bottles though as Thomas Cider only makes Glorious Eggroll for both Steam and for Lutris. Nothing is made for Bottles.

https://github.com/GloriousEggroll - Top left is for Steam and Top right is for Lutris. These can be automatically downloaded and kept up to date in Lutris. Lutris can also pull and use whatever Proton you have in Steam. Glorious Eggroll, if using Vulkan, can actually have better frame rates than Windows Native too.

Anyway, you probably have tried Bottles by now. Let me know what you think. You also might be able to roll Glorious Eggroll into Bottles. That is something I would try if I ran it.