bombe_zwanzig: I tried to play vanilla right now, cause i know it's buggy under win7, but the lines in the fallout .ini which alter the multicore-behaviour have been changed by GOG already. it should run. should. hmpf.
edith reminds me: i also changed compatibility to xp sp3 and gave admin rights.
Thiev: it happened to me once on my own (not testlab) machine - I had to switch to windowed mode for initial boot and after that it was safe to play in fullscreen.
but I couldn't get a reliable repro and my PC has lots of weird stuff floating around, so I just ignored it.
nope. tried that just now and still the same. and it does this from wherever i start the game, galaxy, startmenue, just the exe-file. doesn't matter.
so to sum up what i tested:
xp sp3 compatibility
start as admin
windowed mode
switched off second monitor via settings
so far no fallout for me :(