The problem seems to exist on Vista and higher.
But I found a great fix for all problems :)
first step: Download the killap patch 1.02.26
http://www.atomicgamer.com/files/85637/killaps-unofficial-fallout-2-patch-1-02-26-exe Install it.
second step: install the High Resolution Pack 2.2c
http://www.nma-fallout.com/forum/dload.php?action=file&file_id=1295 Install it. (Extract it to the fallout2 directory and run f2_res_patcher.exe)
last step:
open ddraw.ini (in the fallout2 directory) and change line 55 to "Mode=4"
Like this one:
[Graphics]
;Set to 0 for 8 bit fullscreen
;Set to 4 for dx9 fullscreen
;Set to 5 for dx9 windowed
;A dx9 mode is required for any graphics related script extender functions to work (i.e. fullscreen shaders)
;Modes 1, 2 and 3 are no longer supported
Mode=4
---
Now everything is working fine for Vista, 7 and some versions of XP!
(Sorry if my english isn't so good...)