Here is the good one:
http://www.n1nj4.com/EvilPlanet/TheGame/mod_unofficialpatch.php

Does the 1.1 patch fix the research/autosave bug?

Taken from the website of the link, for ease of reference:
Unofficial Patch
An unofficial patch put together by forum member "walking fishy" which should please a few frustrated players...
This patch, which I should again remind you is totally unofficial, is a neat little collection of fixes and updates designed for the US release of the game. You can download it directly from this site here, but I should warn you that installing this patch is likely to mean there will be difficulties in installing any further official patches (which could force you to do a clean install).
With that in mind, the following fixes are in this (self installing) patch:
Fixed the hanchmen stats, the times for acts of infamy are reduced like they should be, as are the heat ratings.
Population is now 150, instead of 100.
Can build all building in the hotel hub and hotel wings.
Can build hotel doors any where, they are cheaper than normal doors but weaker.
Sentry guns can be built inside as well as out.
Hotel casino, lounge and lobby can now be built inside the base.
The loot item Persian rug can now be walked on.
All gun cabinates can now be built in the barracks.
Removed the annoying BEEP BEEP sound on the control room.
Monkey cage (oliver, from an act of infamy should now be researchable).
Prisioners will live longer in the cell.
Most into movies skipped.
Hiding time on world dominition map is now 10mins.
Only sentry guns can be built in building, not disgiused ones.
Freaks shouldnt set traps off now, or at least not as much.
All loot items should carry over to the second island.
Totem pool is only transferable once complete, since it cant be put together on second island.
Fire Extinguisher placable in the hotel.
BodyGuard is now useful.
Security Cameras and speakers can be built in Hotel.

Well... I got the patch... and now when I try to start the game it gives me the following error...
"Wrong disc inserted. Please insert the original Evil Genius Play CD."
Horray :(
Any ideas?

Works for me as well. No issues with CD required.

Are you sure you use the GOG version?

Hi Elwin, I think he's fixed it now. Another thread was opened and I pointed him to the link again (the unofficial patch is just a self-extracting rar archive with text files, ini files and language files, no exe's.

I think the confusion lies in the fact that the patch says it'll change the text from "Load Save" to "Load and Save" yet it still says "Load Save".
However the text readme DOES say that this is 1.01.
Thanks again for this game, 9.99 for Evil Genius is such a steal I worry that Mamba is going to pop in my room and take it back.

No, the confusion is that the official patch is 1.01, but that there is also an UNofficial patch which is version 1.1

Just a note, not good practice to raise posts back from the dead, as it were. This thread is over a year old.
But anyway, here is my posting about how I installed the game and got it all working and patched. Maybe it will help you.
http://www.gog.com/en/forum/evil_genius/installation_setup

Please correct me if any of the information that I have below is inaccurate or misleading
I currently own the original unpatched version of Evil Genius, the Steam version and the patch to fix the game. The EvilGeniusExeStub-Release.exe versions are shown below:
GOG version:
File description: Evil Genius Executable
Type: Application
File version: 1.0.0.0
Product name: Evil Genius
Copyright: Copyright 2004
Size 3.10 MB
Date Modified: 3/2/2009 6:16 PM
Language: English (United Kingdom)
Original version:
File description: Evil Genius Executable
Type: Application
File version: 1.0.0.0
Product name: Evil Genius
Copyright: Copyright 2004
Size 4.83 MB
Date Modified: 8/11/2004 9:28 PM
Language: English (United Kingdom)
Original version patched:
File description: Evil Genius Executable
Type: Application
File version: 1.0.0.0
Product name: Evil Genius
Copyright: Copyright 2004
Size 4.83 MB
Date Modified: 11/5/2004 3:15 PM
Language: English (United Kingdom)
Steam Version: (Not installed at this time)
From the original patch release notes:
========================================
This program will upgrade the US version of Evil Genius to fix the issues listed below. You should only install this patch if you currently have the US version installed on your PC. On the next screen, your Evil Genius installation directory will be selected by default.
Note that for all fixes to work properly (particularly the sentry gun research fix) you will need to start a new game after installing the patch. Saved games from an earlier version will load, but may continue to exhibit bugs fixed in this patch.
Fixed in patch v1.01
--------------------
- Disguised sentry gun can now be researched.
- Sentry gun range increased.
- Agent AI fix for rooms behind locked doors.
- Glossary crash fixes for 2 hyperlinks,
- Rare loading crash.
- Rare crash involving monkeys.
- Extra hint added for objective 2 & the mixer.
- The second mess hall counter has been renamed to "mixer".
- Misleading "Load Save" option renamed to "Load and Save".
- Rare crash bug when deleting certain outdoor traps fixed.
- Rare crash bug when locking minions in during construction fixed.
- Minor scripting fix for a couple of objects.
- Minor fixes (text fixes & memory leaks).
- Rare crash in Training Fixed.
- Version added to Options screen.
- Research button sometimes missing when reloading a saved game fixed.
- Crash when saving during death cubicle animation fixed.
- Agent memory crash fixed (when agents are around during room detonation).
- Security desk crash fixed (holding down LMB to move it when it's destroyed).
- Body bag crash fixed (when reloaded and assigned to a destroyed freezer rack).
========================================
With regards to this section of above:
- Version added to Options screen.
It reports V1.01.81929
Neither that information nor the following is available in the GOG version.
- Misleading "Load Save" option renamed to "Load and Save".
I have not gone into the game far enough to attempt the research of the disguised sentry gun or any of the other items at this point. That said this version still crashes in a similar manner to the Steam version and the unpatched version.
To quell my concerns, please itemize which options have been fixed, which binary you used (1.0.0.0 or v1.01.81929) and why the information that I have is not making sense.
If you are going to direct me to the unofficial patch as shown in the forums:
http://www.n1nj4.com/EvilPlanet/TheGame/mod_unofficialpatch.php
Then I will wonder why I purchased this game from your company.
Was my expectation that this would be the fully patched version as stated on your website and release notes unreasonable? As stated above, please let me know if any of the information I have here is either inaccurate or misleading.

You've hit the nail on the head with that line there. UNOFFICIAL patch. GOG only provide the latest official patch, they do not (and probably cannot due to licensing reasons) provide the games with unofficial patches applied.
That line sounds like it is meant to be directed at GOG staff themselves. As such, you should really submit a support request/question to them. Posting here in the forums isn't guaranteed to get GOG staff attention, it's more for the GOG user community.

Totally a good practice. What's the point in having only a piece of information in 5 threads when you can have it all in one?
Thanks to people like you we meet such situations - https://xkcd.com/979/

The "insert CD" problem is caused by installing official 1.01 patch.

So the GOG version still says "Load Save" despite the official patch being applied? Also, it appears that the website hosting the unofficial patch is down.